Dr James Wilton-Ely CChem F澳门六合彩开奖记录
Winner: 2021 Dalton Division mid-career Award: Sir Geoffrey Wilkinson Award
Imperial College London
For contributions to the application of metals in biological sensing and medical imaging.
Celebrate Dr James Wilton-Ely
#澳门六合彩开奖记录Prizes
Many of the challenges we face in healthcare, energy and the environment rely on constructing molecules or materials for specific applications through a knowledge of their fundamental properties.
Carbon monoxide (CO) is known for its toxicity by inhalation, so it is perhaps surprising that it is actually generated in the body as a gaseous messenger to regulate cellular processes. Since this discovery, much remains unknown about its role and mode of action, partly due to the difficulty in detecting CO in cells. Elevated levels of CO in cells are known to be an indicator of disease and inflammation and so its measurement provides important diagnostic information.
With collaborators at Imperial College and in Spain, Dr Wilton-Ely's research group have applied their successful design of sensitive and selective probes for CO sensing in air to the monitoring of this gas in cells. Detection by microscope is achieved using the fluorescence response of the probe, which ‘lights up’ with CO under light of the right wavelength. This fluorescent unit can also act as a ‘molecular rotor’, which rotates at different rates depending on the viscosity of the surrounding cellular medium. The rate of rotation leads to a variation in the lifetime of the fluorescence observed and this can be calibrated to measure viscosity. Using this novel approach, simultaneous readings of both CO and viscosity in cells have been achieved for the first time.The group are currently working with cancer researchers to explore the role of CO in immune suppression, which could lead to more effective cancer treatments.
This innovation could also allow relatively low-cost equipment (such as a microscope with a suitable light source) to be used to provide information on both these markers of disease, for example in biopsies, without the need for analysis in a specialist lab. The relatively low cost instrumentation needed could make a significant difference for diagnosis in parts of the world where specialist labs are only available in major cities.
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