In this course we examine powder properties and their role in these important processes, so that attendees can understand the influence of drug substance properties on formulation development
By the end of the course the attendees will be able to recognise key powder properties which affect process performance, and make improved judgements about how to improve processes.
Day 1
Introduction to powder technology
Regulatory background
Morning鈥攎easuring powder properties
See the impact of material properties on bulk powder behaviour.
Measurements of the following:
Afternoon鈥攎aking tablets and their properties
- how and why particular tablet components are selected and what impact they have on powder properties and tablet behaviour
- Manufacturing method selection and the importance of powder flow
- Mechanisms of powder mixing and segregation
- Powder properties, Critical Quality and Material Attributes, and the
- Effects of blending behaviour and scale on Critical Process Parameters
- The relationship between input material properties and tablet properties
By the end of the course the attendees will be able to recognise key powder properties which affect process performance, and make improved judgements about how to improve processes.
Day 1
Introduction to powder technology
- Key powder properties
- Solid state properties of materials
- Measuring material properties鈥�
- Impact of formulation and process on powder and tablet properties
- Setting (the right) technical specifications for raw materials and deciding on analytical methods and parameters
- Tabletability
- Compressibility
- Compactibility
- Tensile Fracture Stress
- Impact of material properties on tablet properties
Regulatory background
- Developing advance process understanding
- Impact of powder properties on manufacturing method selection and processing properties
- Using powder properties to control manufacturing processes鈥攑ossibilities and limitations
- Sampling excipients
- Sampling intermediates and blends
- Sampling finished products
- Use of Risk and Process Matrixes
- Identifying Critical Process Parameters
Morning鈥攎easuring powder properties
See the impact of material properties on bulk powder behaviour.
Measurements of the following:
- Powder Flow
- Bulk density
- Compressibility
- Particle size and shape
Afternoon鈥攎aking tablets and their properties
- Tabletability
- Compressibility
- Compactibility
- Tensile Fracture Stress
